Pharmaceutics, Free Full-Text

Chronic wound healing represents an impactful financial burden on healthcare systems. In this context, the use of natural products as an alternative therapy reduces costs and maintains effectiveness. Phytotherapeutic gels applied in photodynamic therapy (PDT) have been developed to act as topical healing medicines and antibiotics. The bioactive system is composed of Spirulina sp. (source of chlorophylls) and Copaifera reticulata oil microdroplets, both incorporated into a polymeric blend constituted by kappa-carrageenan (k-car) and F127 copolymer, constituting a system in which all components are bioactive agents. The flow behavior and viscoelasticity of the formulations were investigated. The photodynamic activity was accessed from studies of the inactivation of Staphylococcus aureus bacteria, the main pathogen of hospital relevance. Furthermore, in vivo studies were conducted using eighteen rabbits with dermatitis (grade III and IV) in both paws. The gels showed significant antibiotic potential in vitro, eliminating up to 100% of S. aureus colonies in the presence or absence of light. The k-car reduced 41% of the viable cells; however, its benefits were enhanced by adding chlorophyll and copaiba oil. The animals treated with the phytotherapeutic medicine showed a reduction in lesion size, with healing and re-epithelialization verified in the histological analyses. The animals submitted to PDT displayed noticeable improvement, indicating this therapy’s viability for ulcerative and infected wounds. This behavior was not observed in the iodine control treatment, which worsened the animals’ condition. Therefore, gel formulations were a viable alternative for future pharmaceutical applications, aiming at topical healing.

Three Birds, One Excipient: Development of an Improved pH, Isotonic, and Buffered Ketamine Formulation for Subcutaneous Injection—Pharmaceutics

Pharmaceuticals, Free Full-Text

Principles of pharmacoeconomic analysis – Center for International Research and Publishing in Pharmacy Practice

Liquid API Feeding in Pharmaceutical HME: Novel Options in Solid Dosage Manufacturing - ScienceDirect

Pharmacy Technician - CVS

Read Book [PDF] Aulton's Pharmaceutics: The Design and Manufacture of Medicines Full Pages - Issuu

PHP Online Pharmacy Delivery System, 10 Days

Understanding Pharma: The Professional's Guide to How Pharmaceutical and Biotech Companies Really Work by John J. Campbell - Hardcover - 2008 - from Revaluation Books (SKU: __0976309637)

Pharmaceutics, Free Full-Text