The role played by alternative splicing in antigenic variability in human endo-parasites, Parasites & Vectors
Por um escritor misterioso
Last updated 30 maio 2024
Endo-parasites that affect humans include Plasmodium, the causative agent of malaria, which remains one of the leading causes of death in human beings. Despite decades of research, vaccines to this and other endo-parasites remain elusive. This is in part due to the hyper-variability of the parasites surface proteins. Generally these surface proteins are encoded by a large family of genes, with only one being dominantly expressed at certain life stages. Another layer of complexity can be introduced through the alternative splicing of these surface proteins. The resulting isoforms may differ from each other with regard to cell localisation, substrate affinities and functions. They may even differ in structure to the extent that they are no longer recognised by the host’s immune system. In many cases this leads to changes in the N terminus of these proteins. The geographical localisation of endo-parasitic infections around the tropics and the highest incidences of HIV-1 infection in the same areas, adds a further layer of complexity as parasitic infections affect the host immune system resulting in higher HIV infection rates, faster disease progression, and an increase in the severity of infections and complications in HIV diagnosis. This review discusses some examples of parasite surface proteins that are alternatively spliced in trypanosomes, Plasmodium and the parasitic worm Schistosoma as well as what role alternate splicing may play in the interaction between HIV and these endo-parasites.
Construction and Deciphering of Human Phosphorylation-Mediated Signaling Transduction Networks
From cradle to grave: RNA biology in malaria parasites - Hughes - 2010 - WIREs RNA - Wiley Online Library
Translational regulation in blood stages of the malaria parasite Plasmodium spp.: systems‐wide studies pave the way - Vembar - 2016 - WIREs RNA - Wiley Online Library
Leishmania tarentolae: Taxonomic classification and its application as a promising biotechnological expression host. - Abstract - Europe PMC
What helminth genomes have taught us about parasite evolution, Parasitology
Read, Write, Adapt: Challenges and Opportunities during Kinetoplastid Genome Replication: Trends in Genetics
PDF) The role played by alternative splicing in antigenic variability in human endo-parasites
Biomolecules, Free Full-Text
Post-transcriptional regulation of gene expression in human malaria parasite Plasmodium falciparum - ScienceDirect
Recomendado para você
-
PepperPixel - Hobbyist, General Artist30 maio 2024
-
Card Games SCP Foundation Card Paper Blind Box Shelter 049 Monster30 maio 2024
-
Whipple 6 Rib Supercharger Pulley (2014+ GM DI LT1) SCP-6-GMT30 maio 2024
-
Dragons Great Hall in Environments - UE Marketplace30 maio 2024
-
Vietnam National Action Plan on SCP (2021-2030) ›30 maio 2024
-
PTFE Fabric Curbell Plastics30 maio 2024
-
ArtStation - Quick Lib30 maio 2024
-
🦃 Gobbling Turkey Snood30 maio 2024
-
PDF] Prevalence of gastrointestinal disorders in individuals with
RASopathies : MayRAS /MAP /ERK pathway dysfunctions be a model of neuropathic pain and visceral hypersensitivity? by Chiara Leoni30 maio 2024 -
ArtStation - Woman Farmer30 maio 2024
você pode gostar
-
DOA - Dead or Alive trailer30 maio 2024
-
Lote 2 - Caixa com 4 jogos tabuleiro Majora Jogos Reunidos- conjunto antigo, completo e em bom estado geral. Inclui os Jogos Ludo, Os Cow-boys e a Mina, Corrida de Cavalos e30 maio 2024
-
Uncharted 4 PC Port Leaked by PlayStation Investor Report - Xfire30 maio 2024
-
Create a Stunning and Irresistible Instagram Account30 maio 2024
-
ChessBase 17 Steam Edition Crack Status30 maio 2024
-
Redengine czy unex executor? - Grand Theft Auto V - Dyskusje / problemy - - czity, bugi, hacki, boty do gier30 maio 2024
-
Roblox > Conta Roblox - Mais de 26 mil robux gastos30 maio 2024
-
Ayaka: A Story of Bonds and Wounds Subtitle Indonesia - SOKUJA30 maio 2024
-
Esportes, Agemt30 maio 2024
-
File:DETROIT BECOME HUMAN Walkthrough Gameplay Part 16 - CLUB EDEN (PS4 Pro)-(063674)2018-05-29-01-04-28-.JPG - FembotWiki30 maio 2024